Scientific research
Fenugreek Seed Extract (Trigonella foenum-graecum): for Thinning Hair and Bald Spots
In vivo Hair Growth Activity of Herbal Formulations: Read here
Effectiveness test of Fenugreek Seed (Trigonella foenum-graecum L.) Extract hair tonic in Hair Growth Activity: Read here
Fenugreek+micronutrients: Efficacy of a food supplement against hair loss: Read here
Trigonella (Fenugreek) Improves Sexual Function in Women: Read here
Physiological aspects of male libido enhanced by standardized Trigonella foenum-graecum extract and mineral formulation: Read here
HE SHOU WU (POLYGONUM MULTIFLORUM)
Hair Growth Promotion Activity and Its Mechanism of Polygonum multiflorum: Read here
‘Many studies had found that FGF (fibroblast growth factor) shows obvious adjustment to the hair growth. FGF could promote hair to enter the anagen stage and increase hair follicles amounts. Vascular endothelial growth factor (VEGF), a multifunctional cytokine, could not only induce the formation of blood vessels around hair follicles, but also promote directly the dermal papilla cells proliferation’
Polygonum Multiforum and potential role in hair growth: Read here
‘A large study was conducted on 507 participants to observe the effects of Fo Ti or Polygonum multiflorum on hair loss, when taken orally (1). After collecting and analyzing their data, the researchers found:
- 77% of the participants experienced significantly reduced hair loss.
- 95% of the subjects noticed that issues with excessive shedding had stopped.
- 90% of the men and women who took part in this study displayed noticeable improvement in new growth after 6 months of taking the polygonum multiflorum hair loss treatment.’
NETTLE ROOT EXTRACT (URTICA DIOICA) (IN COMBINATION WITH BETASITOSTERAL)
Proprietary Herbal Extract Down regulates the Gene Expression of IL-1α in HaCaT Cells: Possible Implications Against Non scarring Alopecia: Read here
‘Among the plants used in our formulation Urtica dioica (Ud) is the most widely studied one. Symptomatic benign prostate hyperplasia (BPH) is the best researched indication of this plant which is mainly due to its 5α-R inhibition activity (23, 24, 25).
Inhibition of 5α-R precludes the conversion of testosterone to dihydrotestosterone (DHT) high levels of which are associated with BPH (26). The same pathogenesis is also valid for AGA (3,4). Although Ud leaves have traditionally been used for hair loss, confirmatory clinical trials are still lacking (26).
In a study performed with a combination of herbal extracts including Ud, the combination was found to increase the proliferation of human dermal papilla cells significantly at concentrations ranging from 1.5% to 4.5% (27). Ud contains β sitosterol which stimulates angiogenesis by increasing vascular endothelial growth factor (VEGF) synthesis and supports new hair growth (28).’
Pygeum (Pygeum Africanum)
Pygeum Africanum: Natural DHT Blocker and Hair Loss Treatment: Read here
Adverse effects due to Pygeum Africanum were mild and comparable to placebo.” This is relevant to hair loss sufferers as both BPH and androgenetic alopecia are linked to DHT. A reduction in DHT almost always means a reduction in BPH symptoms, suggesting Pygeum africanum may work by reducing levels of this hormone.
And of the many natural DHT blockers out there, Pygeum africanum is the most promising. It follows from this that Pygeum africanum should stop hair loss from progressing. As an added bonus, Pygeum africanum has been shown to have anti-inflammatory properties as well.
Horsetail (Equisetum arvense)
Inhibition of 5α-Reductase, IL-6 Secretion, and Oxidation Process of Equisetum debile Roxb. ex Vaucher Extract as Functional Food and Nutraceuticals Ingredients: Read here
‘According to the highest inhibitory activity against 5α-reductase and lipid peroxidation, as well as, high IL-6 secretion reduction, EA was the most attractive extract for anti-hair loss.’
Saw Palmetto 25% Berry Extract (Serenoa Repens)
Serenoa repens extracts promote hair regeneration and repair of hair loss mouse models by activating TGF-β and mitochondrial signaling pathway: Read here
‘LSESr (liposterolic extracts of Serenoa repens ) promoted the hair regeneration and repair of hair loss mouse models by activating TGF-β signaling and mitochondrial signaling pathway.
Beta-Sitosteral
Proprietary Herbal Extract Downregulates the Gene Expression of IL-1α in HaCaT Cells: Possible Implications Against Non scarring Alopecia: Read here
‘..contains β sitosterol which stimulates angiogenesis by increasing vascular endothelial growth factor (VEGF) synthesis and supports new hair growth (28).’
Biotin/zinc
Serum biotin and zinc in male androgenetic alopecia: Read here
‘Serum biotin showed a suboptimal level in MAGA (Male androgenetic alopecia) patients that is not correlated with patients’ age or disease severity. Biotin supplement in MAGA treatment may add value to hair quality and texture.
A review of the use of Biotin for Hair Loss: Read here
Results: We found 18 reported cases of biotin use for hair and nail changes. In all cases, patients receiving biotin supplementation had an underlying pathology for poor hair or nail
Rosemary Essential Oil (Hairgenx Coco Massage)
Rosemary oil vs minoxidil 2% for the treatment of androgenetic alopecia: a randomized comparative trial.
The present study aimed to investigate the clinical efficacy of rosemary oil in the treatment of androgenetic alopecia (AGA) and compare its effects with minoxidil 2%. Both groups experienced a significant increase in hair count at the 6-month endpoint compared with the baseline and 3-month endpoint (P < .05). Scalp itching, however, was more frequent in the minoxidil group at both assessed endpoints (P < .05). The findings of the present trial provided evidence with respect to the efficacy of rosemary oil in the treatment of AGA.
